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KMID : 1130320110540030127
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Korean Journal of Pediatrics
2011 Volume.54 No. 3 p.127 ~ p.131
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Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors
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Ji Sun-Tae
Chueh Hee-Won
Kim Ju-Youn
Lim Su-Jin
Cho Eun-Joo
Lee Soo-Hyun
Yoo Keon-Hee
Sung Ki-Woong
Koo Hong-Hoe
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Abstract
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Purpose : Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in pediatric IC-GCTs patients according to the risk group, and compared the results with those of the previous cisplatin-based chemotherapy.
Methods : We examined 35 patients (27 men and 8 women) diagnosed with IC-GCTs between August 2004 and April 2008 and received riskadapted carboplatin-based chemotherapy at the Samsung Medical Center. Patients were divided into either low-risk (LR) or high-risk (HR) groups and a retrospective analysis was performed using information from the medical records.
Results : Although hematological complications were common, hearing difficulties or grade 3 or 4 creatinine level elevation were not observed in patients who underwent carboplatin-based chemotherapy. The frequency of febrile neutropenia did not differ between the risk groups. The overall survival was 100% and event-free survival (EFS) was 95.7 %. The EFS rate was 100% in the LR group and 90% in the HR group, respectively.
Conclusion : Despite their common occurrence in high-risk patients, no lethal hematological complications were associated with carboplatinbased treatment. The current carboplatin-based chemotherapy protocol is safe and effective for the treatment of pediatric patients with IC-GCTs.
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KEYWORD
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Intracranial germ cell tumor, Carboplatin, Adverse effects
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